Endocrine Abstracts

Therapeutic interferon-β (IFN-β) preparations have been approved for treatment for multiple sclerosis (MS). However, the development of neutralising antibodies (NAbs) against IFN-β in MS patients reduces therapeutic efficacy. Early detection of NAbs is critical for the modification of treatment regimes. IFN-β exerts its biological effects by binding to receptors on target cells and stimulating the expression of IFN-β-inducible genes. Measurement of end...

Introduction: Recent randomised controlled trials have demonstrated the efficacy of very low calorie diets (VLCD) in carefully selected patients with type 2 diabetes mellitus (T2DM). However, there is paucity of evidence regarding the efficacy of VLCD in the real-world setting. We evaluated outcomes in obese T2DM patients who underwent VLCD at our institution.Methods: This retrospective observational study included all patients who had undergone VLCD fro...